Micro- and nanoparticle-based vaccines for hepatitis B.

摘要: The incredible success of vaccinations in contributing to public health is undeniable.In fact, vaccines are the most cost-effective tool for disease preventionbecause their cost less than combined costs treatment, hospitalization, and time lossfrom work. However, despite availability vaccines, per dose a factor limiting thesuccess global vaccination campaigns, as limitations imposed by need deliveringmultiple vaccine doses. A number approaches being tested particularly deliveryof subunit recent years, groups have devoted efforts todevelop nano/microparticles prepared from biodegradable biocompatible polymers asvaccine delivery systems with goal inducing both humoral cellular immune responses.Some important properties documented safetyhistory, biocompatibility, an ability provide controlled time/rate antigen release andpolymer degradation. extensively studied polymer used encapsulating vaccineantigens poly (lactide-co-glycolide acid) (PLGA). This chapter deals brief effortstargeting use PLGA micro-and nanoparticles hepatitis B surfaceantigen.