作者: Maria Hepel , Chuan-Jian Zhong , Hoda Ilkhani
DOI: 10.3390/NANO11051326
关键词:
摘要: Safe administration of highly cytotoxic chemotherapeutic drugs is a challenging problem in cancer treatment due to the adverse side effects and collateral damage non-tumorigenic cells. To mitigate these problems, promising new approaches, based on paradigm controlled targeted drug delivery (TDD), utilizing nanocarriers with biorecognition ability selectively target neoplastic cells, are being considered therapy. Herein, we report design testing nanoparticle-grid biosensing platform aid development nanocarriers. The proposed sensor grid consists superparamagnetic gold-coated core–shell Fe2Ni@Au nanoparticles, further functionalized folic acid targeting ligand, model thiolated doxorubicin (DOX), biocompatibility agent, 3,6-dioxa-octanethiol (DOOT). employed dual transduction method electrochemical enhanced Raman scattering detection has enabled efficient monitoring loading onto nanocarriers, attaching surface, as well release under simulated intracellular conditions. grid’s nanoparticles serve here for TDD systems optimization. properties NPs nanoparticles’ handling constructing dense high plasmonic enhancement signals minimal interparticle distance.