Semliki Forest virus temperature-sensitive mutants: Isolation and characterization

作者: K.B. Tan , J.F. Sambrook , A.J.D. Bellett

DOI: 10.1016/0042-6822(69)90155-X

关键词:

摘要: Abstract The normal replication of Semliki Forest virus involves RNA synthesis followed by the two structural proteins (nucleocapsid and membrane). Temperature-sensitive mutants blocked at different steps growth cycle have been isolated from chemical mutagenesis. A group defective in (RNA − mutants) were prevented producing viral antigen cells infected restrictive temperature also unable to inhibit host cell synthesis. factor affecting is expressed early cycle. Other functions subsequent + mutants). Some production nucleocapsids only; others failed make membrane only. few made both proteins, but not infectious virus, may be a maturation function.

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