Renal cell carcinoma in children and adolescents

摘要: Although rare in children and adolescents, renal cell carcinomas (RCCs) raise important questions concerning the best treatment approach accurate pathologic classification. The differences emerging between childhood adulthood RCC probably prevent any direct generalized application of therapies to that are validated for adults. translocation type RCC, which forms a distinct category characterized by translocations involving Xp11.2 or, less frequently, 6p21, has recently emerged as predominant whereas it is rarely diagnosed This new finding emphasizes how prospectively classify RCCs with standardized 'modern' diagnoses. standard cornerstone therapy adolescents remains radical nephrectomy. Nephron-sparing surgery currently recommended adults selected small-volume tumors, but additional data needed before this experience can be extensively transferred pediatric population. therapeutic value complete retroperitoneal lymph node dissection still controversial, especially patients without suspected nodal involvement, they or children. backbone systemic adult been changed introduction drugs designed target tumor-related angiogenesis signal transduction. It worth noting largest clinical efficacy trials on targeted molecules have conducted clear-cell RCC. While become care metastatic there no published reports their role children, use should considered unresectable advanced-stage On other hand, utility adjuvant setting seen both