Epigenomic Networking in Drug Development: From Pathogenic Mechanisms to Pharmacogenomics
作者： Ramón Cacabelos
DOI: 10.1002/DDR.21219
关键词:
摘要: … molecules by DNA methyltransferases (DNMTs), forming 5-… (DNMTs), which in mammals are represented by two de novo DNMts (DNMT3A, DNMT3B), and a maintenance DNMT (…
sci-hub.se 参考文章(94)
Yitshak I. Francis, Mauro Fà, Haider Ashraf, Hong Zhang, Agnieszka Staniszewski, David S. Latchman, Ottavio Arancio, Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease. ,vol. 18, pp. 131- 139 ,(2009) , 10.3233/JAD-2009-1134
Daniel C. Benyshek, The "early life" origins of obesity-related health disorders: new discoveries regarding the intergenerational transmission of developmentally programmed traits in the global cardiometabolic health crisis. American Journal of Physical Anthropology. ,vol. 152, pp. 79- 93 ,(2013) , 10.1002/AJPA.22393
Osamu Ogawa, Xiongwei Zhu, Hyoung-Gon Lee, Arun Raina, Mark E. Obrenovich, Robert Bowser, Hossein A. Ghanbari, Rudolph J. Castellani, George Perry, Mark A. Smith, Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathologica. ,vol. 105, pp. 524- 528 ,(2003) , 10.1007/S00401-003-0684-3
Feng Tian, Ann M. Marini, Robert H. Lipsky, Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons Annals of the New York Academy of Sciences. ,vol. 1199, pp. 186- 193 ,(2010) , 10.1111/J.1749-6632.2009.05175.X
Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlüter, Frank Bradke, Jianrong Lu, André Fischer, Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. Embo Molecular Medicine. ,vol. 5, pp. 52- 63 ,(2013) , 10.1002/EMMM.201201923
Ramón Cacabelos, Pharmacogenomics of Central Nervous System ( CNS ) Drugs Drug Development Research. ,vol. 73, pp. 461- 476 ,(2012) , 10.1002/DDR.21039
Keith E. Szulwach, Peng Jin, Integrating DNA methylation dynamics into a framework for understanding epigenetic codes BioEssays. ,vol. 36, pp. 107- 117 ,(2014) , 10.1002/BIES.201300090
Rebecca A. Alyea, B. Bhaskar Gollapudi, Reza J. Rasoulpour, Are we ready to consider transgenerational epigenetic effects in human health risk assessment? Environmental and Molecular Mutagenesis. ,vol. 55, pp. 292- 298 ,(2014) , 10.1002/EM.21831
Gizem Donmez, Diana Wang, Dena E. Cohen, Leonard Guarente, SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 Cell. ,vol. 142, pp. 320- 332 ,(2010) , 10.1016/J.CELL.2010.06.020
Christina Brahe, Tiziana Vitali, Francesco D Tiziano, Carla Angelozzi, Anna Maria Pinto, Federica Borgo, Umberto Moscato, Enrico Bertini, Eugenio Mercuri, Giovanni Neri, Phenylbutyrate increases SMN gene expression in spinal muscular atrophy patients. European Journal of Human Genetics. ,vol. 13, pp. 256- 259 ,(2005) , 10.1038/SJ.EJHG.5201320