Development of predictive quantitative retention-activity relationship models of alkaloids by mixed micellar liquid chromatography.
作者： Yu Chen , Li-ping Wu , Cong Chen , Li-ming Ye
DOI: 10.1002/BMC.1272
关键词:
摘要: The mixed micellar liquid chromatography is a mode that uses system of Brij35/SDS (85 : 15) as mobile phase under adequate experimental conditions, can simulate the resting membrane potential and conformation long hydrophilic polyoxyethylene chains remains unchanged. In this article, applications biopartitioning chromatography, using to describe estimate bioactivities alkaloids, has been focused. BMCBrij35/SDS-QRAR models half-life time, volume distribution, plasma clearance area concentration–time curve were obtained Brij35-SDS retention data. aim take look at capability model and/or bioactivity alkaloids. Copyright © 2009 John Wiley & Sons, Ltd.
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