Vaccination strategies in pediatric inflammatory bowel disease

摘要: The incidence of pediatric inflammatory bowel disease (IBD) is rising, as the use immunomodulatory and biological drugs. IBD patients are vulnerable to infections owing disease-related immunological alterations drug-induced systemic immunosuppression. Although many vaccine-preventable, vaccination coverage in insufficient. Current guidelines recommend that children with follow same routine immunization schedule healthy children, avoiding live vaccines during immunosuppressive therapy. Immunization status should be checked at diagnosis, immunized they need. Some studies have demonstrated a suboptimal immune response vaccinations patients, but responsible mechanisms poorly understood. In this manuscript, we provide broad review available data about vaccine rates, immunogenicity safety both killed attenuated population; furthermore, comprehensive information regarding current for their household contacts. A search published literature using PubMed (http:// www.ncbi.nlm.nih.gov/pubmed/) database was carried out identify all articles English from 1998 March 2017, following key terms: "inflammatory disease", "vaccination", "immunization", "immunogenicity", "safety" "children".