A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers

摘要: Objective We sought to compare total lidocaine dose and patient comfort when using 1.0% with 1:100,000 epinephrine versus 0.5% 1:200,000 during Mohs micrographic surgery. Methods In all, 149 patients were randomized receive or The of measures recorded. Results Compared the group, there was a 52% reduction in group (mean difference, 147.85 mg; 95% confidence interval, 108.15-187.55; P = .48) mean volumes rescue administered ( .18). Limitations No blood levels measured, one surgeon performed all surgeries. Conclusion provides pain control equivalent at approximately half dose.