Splenosis is regulated by a circulating factor

摘要: Abstract Splenic rupture may result in splenosis, the growth of splenic fragments. We used a parabiotic model to test hypothesis that splenotic is governed by circulating mediator(s). Pairs C57B1/6 mice underwent side-to-side anastomosis. After 2 weeks, each four groups second operation which one or both partners had sham splenectomy, fragments transplanted into their peritoneums, some combination thereof. Six weeks later, were excised and weighed. Spleen involuted when inserted pairs two intact spleens. In contrast, with spleen set fragments, multiple splenules developed, whose aggregate mass was approximately half (ratio, 0.53 ± 0.04 [mean SE]) original Significantly more splenosis ( P