Utilizing molecular resonance-localized surface plasmon resonance coupling for copper ion detection in plasma.
作者： ReJeana Cary , Sarah Unser , Ilaina Monroe , Joseph Holbrook , Laura Sagle
DOI: 10.1039/D0AN00563K
关键词:
摘要: The rapid, point-of-care detection of copper in plasma can greatly aid a large number diseases where has been implicated to be an important factor, such as cancer, Alzheimer's and Diabetes mellitus. Localized surface plasmon resonance (LSPR) technologies show promise the inexpensive copper, whereas previous platforms are plagued with selectivity sensitivity issues. Herein, we have created sensitive selective on-chip sensor which produce colorimetric reading 60 minutes. assay is based on ‘Click’ chemistry shown little interference other metal ions present plasma. generated from coupling molecular dye LSPR gold nanoparticles. capable measuring concentrations human low 4 μM linear range sensitivity, 20 μM, physiologically relevant range. This robust, should prove useful setting.
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