Practical lessons from theoretical models about the somitogenesis.

摘要: Vertebrae and other mammalian repetitive structures are formed from embryonic organs called somites. Somites arise sequentially the unsegmented presomitic mesoderm (PSM). In mice, a new bilateral pair of somites every two hours rostral PSM. On hand, cells added to caudal side PSM due cell proliferation tail bud. Somite formation correlates with cycles cell-autonomous expression in genes like Hes7. Because somitogenesis is highly dynamic coordinated process, this event has been subjected extensive theoretical modeling. Here, we describe current understanding about mouse embryos an emphasis on insights gained computer simulations. It worth noting that combination experiments simulations uncovered dynamical properties clock such as transcription/translation delays, half-life synchronization mechanism across Theoretical models have also useful provide predictions rigorous hypothesis poorly understood processes mechanisms by which temporal oscillations arrested converted into spatial pattern. We aim at reviewing literature way experimentalists might appreciate resulting conclusions.