Circulating adhesion molecules after short-term exposure to particulate matter among welders.

摘要: Background: Studies from several countries indicate that welders experience increased risk of mortality and morbidity ischaemic heart disease. Although the underlying mechanisms are unclear, vascular responses to particulate matter contained in welding fumes may play a role. To investigate this, we studied acute effects fume exposure on endothelial component function, as measured by circulating adhesion molecules involved leukocyte (sICAM-1 sVCAM-1) coagulation (vWF). Methods: A panel 26 male was repeatedly across 6 h work-shift high day and/or low non-welding day. Personal PM2.5 throughout work-shift. Blood samples were collected morning (baseline) prior period, immediately after following morning. account for repeated measurements, used linear mixed models evaluate (binary) (continuous) each blood marker, adjusting baseline marker concentration, smoking, age time Results: Welding significantly associated with decrease sVCAM-1 afternoon an increase vWF afternoon. Conclusions: The data suggest short-term occupational acutely affect function.