Evaluation of O-alkyl and aryl sulfonyl aromatic and heteroaromatic amidoximes as novel potent DNA photo-cleavers
作者： A. Papastergiou , S. Perontsis , P. Gritzapis , A. E. Koumbis , M. Koffa
DOI: 10.1039/C5PP00439J
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摘要: Several stable O-alkyl and aryl sulfonyl conjugated p-nitro-Ph and o-, m-, p-pyridine N′-hydroxy imidamides, were subjected to UV irradiation at 312 nm with supercoiled circular plasmid DNA pBluescript KS II. The generated amidinyl and sulfonyloxyl radicals led to effective DNA photo-cleavage. Both alkyl and aryl sulfonyl derivatives were active and the order p-pyridine> p-nitro-Ph> o-pyridine> m-pyridine was schematized for the N′-hydroxy imidamides moiety. Calf thymus-DNA affinity studies which comprised UV interactions …
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