Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma.

摘要: Summary The molecular alterations and pathological features of gastric papillary adenocarcinoma (GPA) remain unknown. We examined GPA samples compared their characteristics with those tubular (GTA). Additionally, we identified that vary microsatellite stability. In the present study, from 63 patients 47 GTA were using a combination polymerase chain reaction (PCR)-microsatellite assays PCR-pyrosequencing in order to detect instability (microsatellite instability, MSI; stable, MSS), methylation status (low methylation, intermediate high level), chromosomal AI multiple cancer-related loci. expression levels TP53 Her2 evaluated immunohistochemistry. are statistically different frequency features, including mucinous, poorly differentiated invasive micropapillary components. Clear genetic patterns differentiating could not be hierarchical cluster analysis, but stability was linked overexpression. Methylation also associated development instability. However, no differences suggest although subset GPAs closely stability, they play minor role carcinogenesis.