Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology

摘要: Distribution of antibody-based therapeutics from the vascular space to target tumor compartment is an important consideration in designing oncology drugs. Mouse models represent a reasonable approach for exploring antibody biodistribution. In general, number factors such as molecular size, dose, and length vivo exposure can influence localization penetration. With few exceptions, current available data indicate that at clinically relevant doses (ranging 1 10 mg/kg) over clinical time (days rather than hours), biodistribution into tumors unlikely be most significant factor hindering efficacy therapeutics. Other antigenic heterogeneity leading variable distribution drugs tumor, or intrinsic resistance antibody-mediated effects, may play far greater role properties impacting profiles.