Mechanisms and Genetics of Drug Transport

摘要: The processes of drug absorption, distribution, metabolism, and excretion (ADME) include transport steps that are mediated by membrane-bound carriers or transporters. Over 400 membrane transporters have been annotated in the human genome, belonging to two major superfamilies: ATP-Binding Cassette (ABC) Solute Carrier (SLC). Most cloned, characterized, localized tissues polarized cellular domains (apical basolateral) body. physiological roles supplying nutrients, removing waste products, maintenance cell homeostasis, signal transduction, energy maintain motility, etc. Although more than identified, only approximately 30 known be important for transport. Numerous preclinical clinical studies now suggest is an determinant pharmacokinetics (PK) pharmacodynamics (PD) because mechanisms control access many drugs various their site action. In some instances, may represent rate-limiting step elimination, involved drug–drug interactions. There growing appreciation importance understanding impact on development role determining efficacy toxicity outcomes.