Surrogate endpoints: a basis for a rational approach.
作者： J. -P. Boissel , J. -P. Collet , P. Moleur , M. Haugh
DOI: 10.1007/BF02333016
关键词:
摘要: In clinical trials, the endpoint is often replaced by an intermediate endpoint, known in some instances as a “surrogate” endpoint. The reasons for substitution are both practical and financial. At present, no theoretical basis or guidelines exist to help choice of surrogate endpoints.
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