Possibilities of detecting health effects by studies of populations exposed to chemicals from waste disposal sites.

摘要: Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such studies will most likely be prompted either by a known release chemicals into environment around site, or unusual disease cluster in population near site. In latter situation, method for evaluating is needed, and one approach discussed. former it may not obvious what outcomes relevant. Reported associations between humans were Studies occupational environmental literature classified target organ affected presented tabular form. No attempt was made to critically evaluate quality evidence each effect, although bibliographic documentation provided where possible. Episodes contamination food, drinking water other media also reviewed separate table. The toxic depend heavily on route exposure dose that received. Ingestion frequently reported episodes contamination. These have hepatic, renal, hematopoietic, reproductive, central nervous systems. type severity dose-dependent. Direct skin contact important dermal system been but seems less as populations sites. Inhalation, unless at relative high concentrations result fire, unlikely important, studies.