作者: Jean C.Y. Lo , Michael A. Darracq , Richard F. Clark
DOI: 10.1016/J.JEMERMED.2013.08.102
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摘要: Abstract Background Historically, methylene blue (MB) has been used for multiple purposes, including as an antidote toxin-induced and hereditary methemoglobinemia, ifosfamide-induced encephalopathy, ackee fruit cyanide poisoning; aniline dye derivative, antimalarial agent, antidepressant. Discussion Most recently, the use of MB advocated a potential adjunct in treatment shock states. Our article reviews role septic shock, anaphylactic shock. is proposed to increase blood pressure these states by interfering with guanylate cyclase activity, preventing cyclic guanosine monophosphate production vasodilatation. Summary may be