UV-induced recessive lethals in uvs strains of Neurospora which are deficient in UV mutagenesis.

摘要: Abstract The frequencie of spontaneous and UV-induced recesive lethal mutations were compared for UV-sensitive wild-type heterokaryons Neurospora crassa . These homokaryotic either one two alleles uvs-3 , or uvs-6 uvs + which is known to have mutator effects, recessive lethals found be 4–6 times more frequent than observed in After correction clonal distribution sponatneous mutants, an 2-fold increase was not statistically significantly may been due chance occurrence a few large clones mutants. Treatment with low doses UV (50–200 J/M 2 ) produced very similar overall rates heterokaryons. This means, that contrast results obtained when mutation ad-3 measured, both showed highly significant treated UV. It proposed certain types damage processed into by alternate mechanism from responsible viable mutations.