Dextropropoxyphene induced hepatotoxicity: a report of nine cases

摘要: Nine patients are described with jaundice, upper abdominal pain and malaise attributable to dextropropoxyphene hepatotoxicity. In each case the history was suggestive of large bile duct obstruction. All underwent ultrasound examination percutaneous liver biopsy. Three also endoscopic retrograde cholangio pancreatography. The histological features biopsies concur previously reported cases changes seen on biopsy were remarkably constant, consisting centrilobular cholistasis, portal tract inflammation abnormalities, in all mimicking Fifteen previous probable hepatotoxicity have been described. occurence 9 further at one centre, 6 presenting within 12 months, suggests that it is much more common than assumed may be misdiagnosed as