Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.

摘要: The biological clock has received increasing interest due to its key role in regulating body homeostasis a time-dependent manner. Cancer development and progression been linked disrupted molecular clock; however, melanoma, the of is largely unknown. We investigated effects tumor on micro- (TME) macro-environments (TMaE) non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 cells 2 weeks later animals euthanized every 6 h during 24 h. presence localized significantly impaired tumor-adjacent skin affected oscillatory expression genes involved light- thermo-reception, proliferation, melanogenesis, DNA repair. was reduced compared healthy but still displayed an profile. able cluster using human database distinguish between primary skin. clocks lungs liver (common sites metastasis), suprachiasmatic nucleus (SCN) by presence, leading chronodisruption each organ. Taken altogether, impairs organism’s clocks. suggest that alterations found TME TMaE could impact development, progression, metastasis melanoma; thus, making interesting pharmacological target.