Moxalactam Plus Ticarcillin or Tobramycin for Treatment of Febrile Episodes in Neutropenic Cancer Patients
作者： Victor Fainstein
DOI: 10.1001/ARCHINTE.1984.00350210078014
关键词:
摘要: • Moxalactam disodium In combination with ticarcillin or tobramycin sulfate was used to treat 445 episodes of suspected confirmed infection patients cancer. The majority had leukemia and neutropenla. rate cures during the 231 infections 65% for moxalactam 64% tobramycin. Both regimens were comparable agalpst aerobic gram-negative polymicrobial Infections. gram-positive infections, response 73% tobramycin, 53%. Only three nine enterococcal Infections responded treatment. Thirteen percent all organisms recovered resistant moxalactam. Side effects occurred infrequently; most important coagulopathy due Nephrotoxic in six receiving none those ticarcillin. 39 patients, a superinfection confirmed. Fourteen fungal, enterococcus, one toKlebsiellaspecies. Eleven 14 fungal moxalactamticarcillin group. are equally active Initial treatment presumed neutropenia. (Arch Intern Med1984;144:1766-1770)
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