Phenazine 1-carboxylic acid resistance in phenazine 1-carboxylic acid producing Bacillus sp. B-6
作者： Kyoung Ja Kim
DOI:
关键词:
摘要: Phenazine 1-carboxylic acid (PCA) is an antifungal antibiotic isolated from a culture filtrate of Bacillus sp. B-6 producing aryl CoA synthetase inhibitor. This reported as inhibitor acyl Pseudomonas sp.. was resistant to PCA up 350 ㎍/㎖. We investigated the mechanism resistance PCA. The rate growth in medium containing 100 ㎍/㎖ rapid PCA-free medium. At concentration 300 ㎍/㎖, more than half that control. In this work, we purified and found much less sensitive other source. These findings suggested insensitivity plays important role bacterium.
koreascience.or.kr 参考文章(30)
Fumiyo Kasuya, Yumiko Yamaoka, Kazuo Igarashi, Miyoshi Fukui, Molecular Specificity of a Medium Chain Acyl-CoA Synthetase for Substrates and Inhibitors Biochemical Pharmacology. ,vol. 55, pp. 1769- 1775 ,(1998) , 10.1016/S0006-2952(97)00640-0
K. Kameda, W.D. Nunn, PURIFICATION AND CHARACTERIZATION OF ACYL COENZYME A SYNTHETASE FROM ESCHERICHIA COLI Journal of Biological Chemistry. ,vol. 256, pp. 5702- 5707 ,(1981) , 10.1016/S0021-9258(19)69262-8
Kee Won Kim, Nam Soo Paek, Young Jin Choi, Tae Han Kim, Jung Joon Lee, Jun Namgung, Articles : Effect of α- Glycosidase Inhibitor in Multidrug Resistant Cell Lines Journal of Biochemistry and Molecular Biology. ,vol. 31, pp. 269- 273 ,(1998)
H Martínez-Blanco, A Reglero, M Fernández-Valverde, M.A. Ferrero, M.A. Moreno, M.A. Peñalva, J.M. Luengo, Isolation and characterization of the acetyl-CoA synthetase from Penicillium chrysogenum. Involvement of this enzyme in the biosynthesis of penicillins. Journal of Biological Chemistry. ,vol. 267, pp. 5474- 5481 ,(1992) , 10.1016/S0021-9258(18)42790-1
M S Jetten, A J Stams, A J Zehnder, Isolation and characterization of acetyl-coenzyme A synthetase from Methanothrix soehngenii. Journal of Bacteriology. ,vol. 171, pp. 5430- 5435 ,(1989) , 10.1128/JB.171.10.5430-5435.1989
H Tomoda, K Igarashi, J C Cyong, S Omura, Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. Journal of Biological Chemistry. ,vol. 266, pp. 4214- 4219 ,(1991) , 10.1016/S0021-9258(20)64309-5
Kohei HOSAKA, Masayoshi MISHINA, Takao TANAKA, Tatsuyuki KAMIRYO, Shosaku NUMA, Acyl-coenzyme-A synthetase I from Candida lipolytica. Purification, properties and immunochemical studies. FEBS Journal. ,vol. 93, pp. 197- 203 ,(1979) , 10.1111/J.1432-1033.1979.TB12811.X
Kathleen M. Knights, Michael E. Jones, Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs. Biochemical Pharmacology. ,vol. 43, pp. 1465- 1471 ,(1992) , 10.1016/0006-2952(92)90203-U
Steven J. Steinberg, Susan J. Wang, Do G. Kim, Stephanie J. Mihalik, Paul A. Watkins, Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Biochemical and Biophysical Research Communications. ,vol. 257, pp. 615- 621 ,(1999) , 10.1006/BBRC.1999.0510
Masahiko Hayashi, Yohsuke Imai, Hiroaki Naraba, Hiroshi Tomoda, Satoshi Omura, Sachiko Oh-ishi, Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. Biochemical and Biophysical Research Communications. ,vol. 188, pp. 1280- 1285 ,(1992) , 10.1016/0006-291X(92)91370-6