作者: M.A. Tucker , C.N. Coleman , R.S. Cox , A. Varghese , S.A. Rosenberg
DOI: 10.1056/NEJM198801143180203
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摘要: Abstract We estimated the risk of second cancers among 1507 patients with Hodgkin's disease treated at Stanford University Medical Center since 1968. Eighty-three occurred more than one year after diagnosis, as compared 15.9 expected on basis rates in general population (relative risk, 5.2; 95 percent confidence interval, 4.2 to 6.5). The mean (±SE) 15-year actuarial all was 17.6±3.1 percent, which 13.2±3.1 due solid tumors. leukemia appeared reach a plateau level 3.3±0.6 10 years, whereas non-Hodgkin's lymphoma continued increase, 1.6±0.7 by end follow-up period. tumors did not vary significantly according treatment category, array neoplasms resembling that previously observed populations exposed radiation and immunosuppressed groups. leukemia, although elevated therapy alone 11; confi...