Genome Editing Using Zinc-Finger Nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs)
作者： Hiroshi Ochiai , Takashi Yamamoto
DOI: 10.1007/978-4-431-55227-7_1
关键词:
摘要: Targetable nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like effector (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas), induce DNA double-strand breaks (DSBs) into user-defined sites. DSBs are immediately repaired through the evolutionarily conserved pathways of error-prone non-homologous end joining (NHEJ) or homology-directed repair (HDR). With utilization these processes, researchers have been able to disrupt specific genes, add exogenous elements intended genomic sites, introduce single-nucleotide substitutions, perform many other applications. Consequently, this “genome editing” technology has revolutionized life science field. In addition, potential improve agricultural products be applicable therapeutic use.
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