Preliminary genome-wide association study of bipolar disorder in the Japanese population.
作者： Eiji Hattori , Tomoko Toyota , Yuichi Ishitsuka , Yoshimi Iwayama , Kazuo Yamada
DOI: 10.1002/AJMG.B.30941
关键词:
摘要: Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage study (GWAS) bipolar disorder (BD) Japanese cohorts. First we used Affymetrix 100K GeneChip arrays analysis 107 cases I controls, selected markers that were nominally significant (P < 0.01) at least one three models (1,577 total). In follow-up stage, analyzed these using an Illumina platform (1,526 markers; 51 not designable for platform) independent sample set, which consisted 395 (bipolar + II) 409 controls. also assessed population stratification current samples principal components analysis. After analysis, 89 remained (allelic P 0.05) same allele being consistently over-represented both first stages. However, none after correction multiple-testing by false discovery rates. Sample was virtually negligible. Collectively, this is GWAS BD population. But given small size limited genomic coverage, results should be taken as preliminary.
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