Recent Advances in Solid Dispersion Technology for Efficient Delivery of Poorly Water-Soluble Drugs

摘要: Drug discovery is generally considered as a costly affair and it takes approximately 15 years to reach new chemical entity into the market. Among recent potent drug molecules with most effective pharmacological properties, very few reached for Phase I clinical trial in humans. Unfortunately, historical average reveals an almost 90% overall attrition rate trials. The solubility permeability of are critical factors influencing success drug. Oral delivery systems still continue exist favored, simplest easiest administration route. A huge number potential candidates won't make market or accomplish their maximum capacity except if oral bioavailability enhanced by formulation. drugs will important aspects formulation development. With emergence synthetic methods molecule synthesis chemistry better screening methods, poorly water soluble compounds has dramatically expanded last years. Solid dispersion one techniques can be prepared several methods. It mostly having poor explores hydrophilic polymers either individually combination enhancement solubility. In comparison conventional formulations such tablets capsules, there different which solid dispersions also have many benefits over approaches. increasing solubility, absorption significance technology constantly increasing. main focus this review present advancements area dispersion. This includes account patents on status based formulations.