Serum Insulin-Like Growth Factor II in 44 Patients with Non-Islet Cell Tumor Hypoglycemia
作者： NAOMI HIZUKA , IZUMI FUKUDA , KAZUE TAKANO , YUMIKO OKUBO , KUMIKO ASAKAWA-YASUMOTO
DOI: 10.1507/ENDOCRJ.45.SUPPL_S61
关键词:
摘要: Serum insulin-like growth factor II (IGF-II) was characterized by radioimmunoassay and Western immunoblot in 44 patients with non-islet cell tumor hypoglycemia (NICTH). 31 of NICTH had big IGF-II sera. When the presence tumors from 20 investigated, detected 18 these In two whose did not contain IGF-II, sera detected. six tumors, disappeared decreased after successful removal tumors. These data indicate that could be related to hypoglycemia, increased serum suggests IGF-II-producing NICTH. levels were greater than those 13 without it (Mean±SEM: 723±54 vs. 326±31ng/ml), but elevated found only patients. IGF-I low all lower also low. IGF-II/IGF-I ratios (35.0±2.2 11.5 ±2.4). The present are rare NICTH, ratio useful for screening
sci-hub.se 参考文章(11)
MEGUMI MIYAKAWA, NAOMI HIZUKA, KAZUE TAKANO, IZUMI TANAKA, REIKO HORIKAWA, NORIKO HONDA, KAZUO SHIZUME, Radioimmunoassay for insulin-like growth factor I (IGF-I) using biosynthetic IGF-I. Endocrinologia Japonica. ,vol. 33, pp. 795- 801 ,(1986) , 10.1507/ENDOCRJ1954.33.795
U. WIDMER, J. ZAPF, E. R. FROESCH, Is Extrapancreatic Tumor Hypoglycemia Associated with Elevated Levels of Insulin-Like Growth Factor II? The Journal of Clinical Endocrinology and Metabolism. ,vol. 55, pp. 833- 839 ,(1982) , 10.1210/JCEM-55-5-833
IZUMI FUKUDA, NAOMI HIZUKA, KAZUE TAKANO, KUMIKO ASAKAWA-YASUMOTO, KAZUO SHIZUME, HIROSHI DEMURA, Characterization of Insulin-Like Growth Factor II (IGF-II) and IGF Binding Proteins in Patients with Non-Islet-Cell Tumor Hypoglycemia Endocrine Journal. ,vol. 40, pp. 111- 119 ,(1993) , 10.1507/ENDOCRJ.40.111
J Zapf, H Walter, E R Froesch, Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. Journal of Clinical Investigation. ,vol. 68, pp. 1321- 1330 ,(1981) , 10.1172/JCI110379
J. D. TEALE, V. MARKS, INAPPROPRIATELY ELEVATED PLASMA INSULIN‐LIKE GROWTH FACTOR II IN RELATION TO SUPPRESSED INSULIN‐LIKE GROWTH FACTOR I IN THE DIAGNOSIS OF NON‐ISLET CELL TUMOUR HYPOGLYCAEMIA Clinical Endocrinology. ,vol. 33, pp. 87- 98 ,(1990) , 10.1111/J.1365-2265.1990.TB00469.X
DAVID RON, ALVIN C. POWERS, MURUGAN R. PANDIAN, JOHN E. GODINE, LLOYD AXELROD, Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia. The Journal of Clinical Endocrinology and Metabolism. ,vol. 68, pp. 701- 706 ,(1989) , 10.1210/JCEM-68-4-701
Sumiko Takayama-Hasumi, Yoko Eguchi, Asako Sato, Chihiro Morita, Yukimasa Hirata, Insulin autoimmune syndrome is the third leading cause of spontaneous hypoglycemic attacks in Japan Diabetes Research and Clinical Practice. ,vol. 10, pp. 211- 214 ,(1990) , 10.1016/0168-8227(90)90063-Y
T Enjoh, N Hizuka, J F Perdue, K Takano, H Fujiwara, N Higashihashi, Y Marumoto, I Fukuda, K Sakano, Characterization of new monoclonal antibodies to human insulin-like growth factor-II and their application in western immunoblot analysis. The Journal of Clinical Endocrinology and Metabolism. ,vol. 77, pp. 510- 517 ,(1993) , 10.1210/JCEM.77.2.7688378
J Zapf, E Futo, M Peter, E R Froesch, Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? Journal of Clinical Investigation. ,vol. 90, pp. 2574- 2584 ,(1992) , 10.1172/JCI116152
I. Fukuda, Circulation forms of insulin-like growth factor II (IGF-II) in patient with non-islet cell tumor hypoglycemia. Endocrinology and Metabolism. ,vol. 1, pp. 89- 95 ,(1994)