Hemophilia B (PTC Deficiency, or Christmas Disease)

摘要: In 1947, it was shown by means of a new procedure, the prothrombin consumption test, that blood did not contain thromboplastin either free or in precursor state but formed as result an interaction between platelet factor and what assumed to be at time single plasma constituent which lacking hemophilia.1Five years later Schulman Smith2reported patient whose clinical condition indistinguishable from hemophilia defective prothrombin-consumption corrected known hemophiliac. They concluded their lacked different thromboplastinogen, agent deficient hemophilia, equally essential for formation thromboplastin. No specific name other than X given this factor. Interestingly, week after Smith sent manuscript publication, Aggeler his associates3