Interstitial Pneumonitis Associated with Bleomycin Therapy

摘要: Pulmonary lesions in 37 patients with cancer who were treated Bleomycin studied histologically. The 35 compared control patients. Interstitial pneumonia at different stages of evolution was found 12 receiving the drug; ten these had associated severe respiratory distress. In contrast, only two group similar changes: one subacute radiation pneu-monitis, other, “respirator lung.” Although lungs showed preferential distribution lower lobes and subpleural regions, Bleomycin-induced nonspecific histologically to those induced by many agents affecting air–blood membrane. histologic features included fibrinous exudate, atypical proliferation alveolar cells, hyaline membranes, interstitial intra-alveolar fibrosis, squamous metaplasia epithelial dysplasia distal air spaces.