Oral Contraceptive Use and Bone Density Change in Adolescent and Young Adult Women: A Prospective Study of Age, Hormone Dose, and Discontinuation
作者： Delia Scholes , Rebecca A. Hubbard , Laura E. Ichikawa , Andrea Z. LaCroix , Leslie Spangler
DOI: 10.1210/JC.2010-3027
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摘要: Context: Oral contraceptive (OC) use is common, but bone changes associated with of contemporary OC remain unclear. Objective: The objective the study was to compare mineral density (BMD) change in adolescent and young adult users discontinuers two estrogen doses, relative nonusers. Design Setting: This a prospective cohort study, Group Health Cooperative. Participants: Participants included 606 women aged 14–30 yr (50% adolescents 14–18 yr): 389 [62% 30–35 μg ethinyl estradiol (EE)] 217 age-similar nonusers; there were 172 discontinuers. 24-month retention 78%. Main Outcome Measure: main outcome measure BMD measured at 6-month intervals for 24–36 months. Results: After 24 months, using EE OCs, not those lower-dose had significantly smaller adjusted mean percentage gains than nonusers spine [group means (95% confidence interval between group differences) 1.32 vs. 2.26% (−1.89, −0.13%)] ...
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