Influence of poly(DL-lactide) nanocapsules on the biliary clearance and enterohepatic circulation of indomethacin in the rabbit.
作者： Fawaz Fawaz , François Bonini , Michel Guyot , Anne‐Marie Lagueny , Hatem Fessi
关键词:
摘要: Following intravenous administration, the uptake of colloidal drug carriers by cells mononuclear phagocyte system, mainly Kuppfer cells, may concentrate an encapsulated close to liver parenchymal and facilitate its biliary excretion enterohepatic circulation. To test this hypothesis indomethacin was administered (10 mg/kg) in four groups 10 rabbits each infusion at a constant rate over 2 hr, either free form (aqueous solution) or as nanocapsules prepared from preformed poly(DL-lactide). Unchanged assayed plasma two control (sham-operated) both bile bile-cannulated groups. Pharmacokinetic analysis led conclusion that macrophages reduces concentration enhancing total clearance. This enhancement due increase clearance, result parallel increases drug. It also demonstrated enhance circulation indomethacin.
springer.com
sci-hub.se 参考文章(19)
Klaus Dietzel, Winfried S. Beck, Hans‐Th. Schneider, Gerd Geisslinger, Kay Brune, The biliary elimination and enterohepatic circulation of ibuprofen in rats. Pharmaceutical Research. ,vol. 7, pp. 87- 90 ,(1990) , 10.1023/A:1015847912059
Nazih Ammoury, Hatem Fessi, Jean‐Philippe Devissaguet, Marcelle Dubrasquet, Simon Benita, Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin-loaded poly(d,l-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats. Pharmaceutical Research. ,vol. 8, pp. 101- 105 ,(1991) , 10.1023/A:1015846810474
K. C. Kwan, G. O. Breault, E. R. Umbenhauer, F. G. McMahon, D. E. Duggan, Kinetics of indomethacin absorption, elimination, and enterohepatic circulation in man Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 4, pp. 255- 280 ,(1976) , 10.1007/BF01063617
Daniel E. Duggan, Kaye F. Hooke, Ronald M. Noll, K. Chiu Kwan, Enterohepatic circulation of indomethacin and its role in intestinal irritation. Biochemical Pharmacology. ,vol. 24, pp. 1749- 1754 ,(1975) , 10.1016/0006-2952(75)90450-5
N. Al Khouri Fallouh, L. Roblot-Treupel, H. Fessi, J.Ph Devissaguet, F. Puisieux, Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules International Journal of Pharmaceutics. ,vol. 28, pp. 125- 132 ,(1986) , 10.1016/0378-5173(86)90236-X
M. Cociglio, J. Bres, D. Sauvaire, R. Alric, M. Richard, Pharmacokinetics of an indomethacin pro-drug: apyramide after intravenous administration in dog. European Journal of Drug Metabolism and Pharmacokinetics. ,vol. 16, pp. 275- 280 ,(1991) , 10.1007/BF03189972
N. Chiannilkulchai, N. Ammoury, B. Caillou, J. Ph. Devissaguet, P. Couvreur, Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice. Cancer Chemotherapy and Pharmacology. ,vol. 26, pp. 122- 126 ,(1990) , 10.1007/BF02897257
W.-P. Yu, G.M. Barratt, J.-Ph. Devissaguet, F. Puisieux, Anti-metastatic activity in vivo of MDP-L-alanyl-cholesterol (MTP-Chol) entrapped in nanocapsules. International Journal of Immunopharmacology. ,vol. 13, pp. 167- 173 ,(1991) , 10.1016/0192-0561(91)90095-O
NAZIH AMMOURY, HATEM FESSI, JEAN-PHILIPPE DEVISSAGUET, MONIQUE ALLIX, MICHEL PLOTKINE, ROGER G. BOULU, Effect on cerebral blood flow of orally administered indomethacin-loaded poly(isobutylcyanoacrylate) and poly(DL-lactide) nanocapsules. Journal of Pharmacy and Pharmacology. ,vol. 42, pp. 558- 561 ,(2011) , 10.1111/J.2042-7158.1990.TB07058.X
Susanne Becker, Functions of the human mononuclear phagocyte system (a condensed review) Advanced Drug Delivery Reviews. ,vol. 2, pp. 1- 29 ,(1988) , 10.1016/0169-409X(88)90003-8