Baseline fibrinolytic state and the risk of future venous thrombosis. A prospective study of endogenous tissue-type plasminogen activator and plasminogen activator inhibitor.
作者： Paul M Ridker , Douglas E Vaughan , Meir J Stampfer , Joann E Manson , Caifang Shen
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摘要: BACKGROUNDAlthough isolated abnormalities of plasminogen activation and inhibition have been reported among selected patients with venous thrombosis, it is unclear whether these deficiencies fibrinolysis are important risk factors for thromboembolic disease.METHODS AND RESULTSTo evaluate baseline levels endogenous tissue-type activator (t-PA) inhibitor type 1 (PAI-1) predict the future occurrence proteins were measured in prospectively collected plasma samples from 55 participants Physicians' Health Study who later developed deep thrombosis or pulmonary embolism an equal number age- smoking-matched control subjects remained free vascular disease during a mean follow-up period 60.2 months. Overall, there no statistically significant differences between case PAI-1 (50.5 versus 59.5 ng/ml, p = 0.26), t-PA (13.4 13.3 n...
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