Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion
作者： Zheqing Cai , Gregg L. Semenza
DOI: 10.1007/978-1-59745-199-4_9
关键词:
摘要: Ischemia and reperfusion injury commonly occurs in ischemic heart disease, resulting apoptotic or necrotic cell death. Apoptotic death is highly regulated. Two mechanisms of apoptosis involve the extrinsic receptor pathway intrinsic mitochondrial pathway. Both pathways lead to activation effector caspases, The plays a key role initiating after ischemia reperfusion. phosphatidylinositol 3-kinase (PI3K), protein kinase C (PKC), extracellular signal-regulated (ERK) signaling protect against injury. They inhibit cytochrome c release into cytosol by regulating Bcl-2 family proteins activating mitoKATP channel, thereby blocking process apoptosis.
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