Objective and subjective effects of treatment for testicular cancer on sexual function.

摘要: Objective  To determine whether the treatment of patients with testicular cancer, using cisplatin combined etoposide and bleomycin (BEP) after orchidectomy in those disseminated disease, causes changes sex hormones penile vascularization, possibly related to sexual dysfunction. Patients methods  Ten treated BEP were compared 11 undergoing alone followed by surveillance. Sex hormone levels analysed cavernosal artery duplex ultrasonography performed before at 6 12 months afterward. Patients questioned about their function. After 1 year, a visual erotic stimulation (VES) test was assess rigidity. Results  In contrast surveillance group, BEP-treated had higher follicle-stimulating (4.6 vs 26.5 U/L) luteinizing (1.4 8.2 levels, lower testosterone (21.1 14.7 nmol/L) than baseline. At most compensated hypergonadotrophic eugonadism, but Leydig cell function recovered. Changes peak flow velocities induced local injection papaverine/phentolamine showed no difference between groups orchidectomy. Loss libido erectile dysfunction reported more frequently patients. However, year treatment, satisfying life VES resulted rigid erection nearly all The could not be explained plasma or diminished blood velocities. Conclusions  After being diagnosed morbidity is considerable, within some improvement may expected. induces transient this recovers. Although symptoms angiopathy, seems unaffected. These findings normal VES-evoked rigidity suggest that psychological organically BEP.