Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro
作者： Boon Chin Heng , Tong Cao , Lawrence Walter Stanton , Paul Robson , Bjorn Olsen
DOI: 10.1359/JBMR.040714
关键词:
摘要: A major area in regenerative medicine is the application of stem cells bone reconstruction and tissue engineering. This will require well-defined efficient protocols for directing differentiation into osteogenic lineage, followed by their selective purification proliferation vitro. The development such would reduce likelihood spontaneous divergent lineages on transplantation, as well risk teratoma formation case embryonic cells. Additionally, could provide useful vitro models studying osteogenesis development, facilitate genetic manipulation therapeutic applications. pharmokinetic cytotoxicity/genotoxicity screening tests bone-related biomaterials drugs also use developed review critically examines various strategies that be used to direct lineage
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