Diagnosis and management of Rosai–Dorfman disease involving the central nervous system

摘要: Abstract Introduction: Rosai–Dorfman disease is a benign non-neoplastic proliferative disorder of histiocytes originally described in the cervical lymph nodes. Extranodal sites were later recognized, and by 1990, they shown to represent over 40% cases; however, central nervous system involvement still considered rare. We review literature, which shows steady increase reports involving brain and/or spine. Methods: A literature search was performed for period 1969–2008, using multiple engines, with keywords disease, sinus histiocytosis massive lymphadenopathy. Results: By December 2008, 111 cases had been reported including our cases. In system, ubiquitous. Although it characterized unique, indeed pathognomonic, histopathological cytoarchitecture, m...