Molecular markers in oral epithelial dysplasia: review

摘要: The clinical and histologic features alone cannot accurately predict whether potentially malignant disorders of the oral mucosa remain stable, regress or progress to malignancy. Some them, with without epithelial dysplasia, may transform invasive squamous cell carcinomas (OSCC). Identification molecular markers which can disease progression is necessary improve management these disorders. Many genes signaling pathways have been shown be involved in development OSCC. This review summarizes some researched detection pre-cancer. We highlight selected that are reported significantly associated These include alterations genes/pathways control cellular signaling, cycle, apoptosis, genomic stability, cytoskeleton, angiogenesis, etc. However, genetic tumor so far not gained any use routine diagnosis their utility prediction risk transformation remains unknown. It is, however, clear from large number studies, described this review, multiple normal metaplastic/dysplastic, subsequently cancer. therefore study those significant simultaneously biopsy samples cohorts subjects.