摘要: Abstract Anti-dsDNA antibodies are a hallmark of lupus erythematosus, yet their origin remains debated and the mechanisms by which they contribute to disease continue be investigated. Although some studies demonstrated that elicited in an antigen-driven response from nonautoreactive precursor, other have shown can also arise mature autoreactive B cells become activated inflammatory environment. Both direct indirect anti-dsDNA deposit kidney initiate nephritis been proposed. More recent evidence elucidates subset cross-reacting with N-methyl- d -aspartate receptor on neurons may neuropsychiatric manifestations lupus. In addition, internalization immune complexes has activate pathways myeloid cells, thus initiating feedback loop between innate adaptive immunity. Overall, this review summarizes insights into complexity exert harm.
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