Mechanical and optical methods for breast cancer imaging

摘要: It has been recognized that mechanical and optical properties of tissues can be the indicators to identify characterize breast tumors. The objective this study is develop new modalities for qualification elastic normal cancerous tissues. First, a mammography-based elastography (called elasto-mammography) proposed generate elastogram based on conventional X-ray mammography. displacement information extracted from mammography projections before after compression. With incorporation measurements, an reconstruction algorithm specially developed estimate moduli heterogeneous Case studies with numerical phantoms are conducted demonstrate capability elasto-mammogrpahy. shown methodology stable robust characterization projective measurement. Second, nonlinear elastogrpahy extend material model cases. A three-dimensional (3D) extracting real images including fatty tissue, glandular An exponential-form applied. Based finitedeformation constitutive law, discretized equations solved displacement, strain, stress fields in given tumors under external compression at boundaries. We 3D inverse-problem reconstruct parameters relation For first time, adjoint gradient method introduced improve efficiency enhance stability reconstruction.