Relationship of Activity in the Subthalamic Nucleus–Globus Pallidus Network to Cortical Electroencephalogram

摘要: One of the functions excitatory subthalamic nucleus (STN) is to relay cortical activity other basal ganglia structures. The response STN input shaped by inhibition from reciprocally connected globus pallidus (GP). To examine in STN–GP network relation activity, we recorded single and multiple unit and/or GP together with electroencephalogram anesthetized rats during various states activation. During slow-wave (SWA), neurons fired bursts action potentials at frequencies that were similar those coincident slow (∼1 Hz) spindle (7–14 oscillations. Spontaneous or sensory-driven global activation was associated a reduction SWA shift burst- tonic- irregular-firing. Rhythmic lost when cortex inactivated spreading depression did not resume until had recovered. Although rhythmic correlated SWA, phase relationships activities within between nuclei variable. Even displayed synchronous bursting correlations on millisecond time scale, which might indicate shared synaptic input, observed. These data (1) intimately related hence sleep–wake cycle; (2) oscillatory disease may be driven cortex; (3) regulated space complex manner.