Methods for measurement of vocal fold vibration and viscoelasticity

摘要: The overall aim of the thesis was to develop new methods for analysis vocal fold vibrations and viscoelasticity test them in human subjects. In Study I onset vibration irregular examined with laryngoscopy using a high-speed camera at frame rate about 2000 images/sec. A software called High-Speed Tool Box, HSTB, developed automatic analysis. HSTB can read sound signal present exactly synchronized image. It also trace edges during display area as graph. From recording it is possible make kymogram, which shows one part image, but longer period. Data from subject voice tremor diplophonic phonation are presented. When examining folds rigid or flexible endoscope amplification image differs distance object. study II we adapted laser triangulation method use larynx measure both horizontal distances vertical movements mm-scale. standard error measurements plane between 3-6% 10%. III twenty-seven professional opera singers were sizes related category singers. result showed that bass group had significantly than sopranos mezzos; also, males females (p<0.05). Measured values width larger compared other categories IV measuring viscoelasticity, Air Pulse Elasticity Measure (APEM), developed. be used local anesthesia on By blowing controlled air pulses resulting mucosal deflections help calculate value reflecting elasticity. Nine normal vocally healthy subjects pulse stimulations folds, skin (cheek dorsum hand) inside lip. elasticity data no differences lips cheeks. hand significant higher stiffness three measured tissues (p<0.001). coefficient variation 35% all measurement points, ideal conditions 9%. results indicate technique allows quantitative non-invasive awake even if some methodological development needed before clinically. V APEM scarred rabbit folds. Ten New Zealand 4 directly after sacrifice. elastic histological sections analysed by pathologist. lower (higher stiffness) more samples minor damage (p=0.03). conclusion these reliable practice function. However they clinically useful.