The Effect of Iloprost on Nitric Oxide, Asymmetric Dimethyl Arginine and Serotonin in the Treatment of Peripheral Vascular Disease
作者： Sefa ŞENOL
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摘要: Ozet Amac: Bu calismada periferik arter hastalarinda iloprost kullaniliminin dolasimdaki asetil dimetil arjinin (ADMA), Serotonin ve Nitrik Oksit (NO) gibi endotelyal fonksiyonlarda gorev alan parametreler uzerindeki etkinliginin arastirilmasi hedeflenmistir. Materyal Metod : Calismaya Fontaine III-IV hastaligi tanisiyla takip edilip medikal tedavi karari verilen 30 olgu (19’u erkek, 11’i kadin, yas araligi ise 60.7 ± 13.7 ) alindi. Hastalara infuzyonu on kol venlerinden 0.5-1.5 ng/kg/dk dozunda 16 saatlik intravenoz infuzyon seklinde baslandi 7 gun verildi. Tedavi oncesi sonrasi ( 8. gunde) ADMA, NO sonuclari icin kan Total nitrit (nitrit + nitrat) konsantrasyonu modifiye kadmiyum reduksiyon metodu ile, ADMA serotonin duzeyleri High Performance Liquid Chromotography (HPLC) yontemiyle olculdu. Bulgular: Iloprost tedavisi degeri dusmus olup bu istatistiksel olarak anlamli iken (p=0.001), (p=0.82) (P= 0.16) degerlerindeki degisiklikler anlamsiz bulunmustur. Sonuc: Periferal arteryel hastaliklarda disfonksiyon gostergesi kabul edilen ADMA’nin azaldigini kullanilan tedavinin degerlendirilmesinde dikkate alinabilinecek bir parametre olabilir .
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