Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II‐infused mice
作者： Hiromichi Wakui , Koichiro Sumida , Megumi Fujita , Yuta Ohtomo , Masato Ohsawa
DOI: 10.14814/PHY2.13316
关键词:
摘要: Abstract Plasma membrane calcium pump isoform 1 (PMCA1) is encoded by ATPase plasma Ca 2+ transporting ( ATP2B1 ), the most likely candidate gene responsible for hypertension. Although PMCA1 highly expressed in kidney, little known about regulation of its renal expression various pathological conditions in vivo. Our study was designed to elucidate mice. We employed three mouse models kidney disease. These were unilateral ureteral obstruction (UUO), remnant using 5/6 nephrectomy, and chronic angiotensin II administration models. Mice assessed systolic blood pressure injury accordance with damage induced specific model. Kidney mRNA levels measured all The UUO model showed fibrosis but no changes or expression. Similarly, nephrectomy exhibited declined function without In contrast, increased albuminuria as well significantly increasing protein results suggest that has a role one molecules involved II‐induced hypertension injury.
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