Effect of Oxytocin on Hunger Discrimination.

摘要: Centrally and peripherally administered oxytocin (OT) decreases food intake activation of the endogenous OT systems is associated with termination feeding. Evidence gathered thus far points to as facilitator early satiation, thus, a peptide that reduces meal has already begun. It not known, however, whether can diminish feeling hunger, thereby decreasing perceived need seek calories. Therefore, in current project, we first confirmed intraperitoneal (i.p.) at 0.3-1 mg/kg deprived non-deprived rats. We then used those doses unique hunger discrimination protocol. First, rats were trained discriminate between 22- 2-h deprivation (hungry versus sated state) two-lever operant procedure. After acquired discrimination, they food-restricted for 22 h given i.p. before generalization test session. did decrease 22-h deprivation-appropriate responding match following deprivation, it reduce level hunger. In order better understand mechanisms behind this ineffectiveness OT, c-Fos immunohistochemistry determine activates different subset feeding-related brain sites under deprivation. found animals, induces changes broader network hypothalamic stem compared affected hungry state. Finally, by employing qPCR analysis, asked state have an impact on receptor expression stem, CNS ‘entry’ region peripheral OT. Fasted animals had significantly lower mRNA levels than their ad libitum-fed counterparts. conclude does start meal. Instead OT’s anorexigenic properties are manifested once consumption begun which - least some extent driven responsiveness treatment fed should be viewed mediator satiation rather molecule diminishes