Monocyte Chemoattractant Protein Inhibits the Generation of Tumor-reactive T Cells

摘要: The adoptive transfer of tumor-sensitized T cells can eradicate disseminated malignancy in murine animal models. must be sensitized to tumor antigens vivo acquire antitumor reactivity. T-cell sensitization has been demonstrated dependent on host antigen-presenting cells. Tumor-associated macrophages are a heterogeneous population that may have both inhibitory and stimulatory influences the naive Here we demonstrate weakly immunogenic tumor, MCA 205 sarcoma, produces substantial amounts monocyte chemoattractant protein 1 (MCP-1). Neutralization MCP-1 during resulted possessed enhanced therapeutic activity against established pulmonary metastases. These depletion also exhibited production IFN-γ upon recognition targets. results potent influence development tumor-reactive