Association of mRNA expression level of IP-10 in peripheral blood mononuclear cells with HBV-associated acute-on-chronic liver failure and its prognosis.

摘要: HBV-associated acute-on-chronic liver failure is prevalent in mainland China. The prognosis of HBV-ACLF poor. mortality approximately 80%. Therefore, a prognostic indicator was needed order to allow us intervene as soon possible. model for end-stage disease (MELD) scoring system widely used predict the failure. However, assessment too complex restrict its application. This study aimed investigate expression IP-10 peripheral blood mononuclear cells (PBMC), explore relationship between and patients with HBV-ACLF. mRNA level PBMCs were analyzed 80 HBV-ACLF, 40 chronic hepatitis B (CHB) healthy people by fluorescent quantitative PCR. significantly higher group than other two groups (P<0.01). Group MELD score below 30 had lower over (P<0.05). positive that negative With threshold 0.925, area under receiver operating characteristic (ROC) curves 0.815. These findings suggest would be helpful evaluating severity