RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes

摘要: Gene expression in a tissue-specific context depends on the combined efforts of epigenetic, transcriptional and post-transcriptional processes that lead to production specific proteins are important determinants cellular identity. Ribosomes central component protein biosynthesis machinery cells; however, their regulatory roles translational control gene skeletal muscle remain be defined. In genetic screen identify critical regulators myogenesis, we identified DEAD-Box RNA helicase, DDX27, is required for growth regeneration. We demonstrate DDX27 regulates ribosomal (rRNA) maturation, thereby ribosome biogenesis translation transcripts during myogenesis. These findings provide insight into regulation myogenesis suggest novel functions ribosomes regulating muscles.