作者: Lucien Abenhaim , Yola Moride , François Brenot , Stuart Rich , Jacques Benichou
DOI: 10.1056/NEJM199608293350901
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摘要: Background Recently in France, primary pulmonary hypertension developed a cluster of patients exposed to derivatives fenfluramine appetite suppressants (anorexic agents), which are used for weight control. We investigated the potential role anorexic agents and other suspected risk factors hypertension. Methods In case–control study, we assessed 95 with from 35 centers Belgium, United Kingdom, Netherlands 355 controls recruited general practices matched patients' sex age. Results The use drugs (mainly fenfluramine) was associated an increased (odds ratio any anorexic-drug use, 6.3; percent confidence interval, 3.0 13.2). For preceding year, odds 10.1 (95 3.4 29.9). When were total more than three m...