Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

作者: Lucien Abenhaim , Yola Moride , François Brenot , Stuart Rich , Jacques Benichou

DOI: 10.1056/NEJM199608293350901

关键词:

摘要: Background Recently in France, primary pulmonary hypertension developed a cluster of patients exposed to derivatives fenfluramine appetite suppressants (anorexic agents), which are used for weight control. We investigated the potential role anorexic agents and other suspected risk factors hypertension. Methods In case–control study, we assessed 95 with from 35 centers Belgium, United Kingdom, Netherlands 355 controls recruited general practices matched patients' sex age. Results The use drugs (mainly fenfluramine) was associated an increased (odds ratio any anorexic-drug use, 6.3; percent confidence interval, 3.0 13.2). For preceding year, odds 10.1 (95 3.4 29.9). When were total more than three m...

参考文章(26)
Antoine Hadengue, Mohamed Kamal Benhayoun, Didier Lebrec, Jean-Pierre Benhamou, Pulmonary hypertension complicating portal hypertension: prevalence and relation to splanchnic hemodynamics. Gastroenterology. ,vol. 100, pp. 520- 528 ,(1991) , 10.1016/0016-5085(91)90225-A
Peter J. McDonnell, Patryce A. Toye, Grover M. Hutchins, Primary pulmonary hypertension and cirrhosis: are they related? The American review of respiratory disease. ,vol. 127, pp. 437- 441 ,(2015) , 10.1164/ARRD.1983.127.4.437
M Fahlen, H Bergman, G Helder, L Ryden, I Wallentin, L Zettergren, Phenformin and pulmonary hypertension. Heart. ,vol. 35, pp. 824- 828 ,(1973) , 10.1136/HRT.35.8.824
P Petitpretz, F Brenot, R Azarian, F Parent, B Rain, P Herve, G Simonneau, Pulmonary hypertension in patients with human immunodeficiency virus infection. Comparison with primary pulmonary hypertension. Circulation. ,vol. 89, pp. 2722- 2727 ,(1994) , 10.1161/01.CIR.89.6.2722
A.T. Masi, Pulmonary Hypertension and Oral Contraceptive Usage Chest. ,vol. 69, pp. 451- 453 ,(1976) , 10.1378/CHEST.69.4.451B
Wallace T. Miller, Gerard J. Sais, Ian Frank, Warren B. Gefter, Judith M. Aronchick, Wallace T. Miller, Pulmonary Aspergillosis in Patients With AIDS: Clinical and Radiographic Correlations Chest. ,vol. 105, pp. 37- 44 ,(1994) , 10.1378/CHEST.105.1.37
Charles B. Howard, Meir Nyska, Itzchak Meller, Eleanor Goshen, Martha Mozes, Ian J. Cohen, Transient swelling of the costochondral and sternal region in infants. Chest. ,vol. 105, pp. 29- 31 ,(1994) , 10.1378/CHEST.105.1.29
Philipe Hervé, Jean-Marie Launay, Marie-Laurène Scrobohaci, François Brenot, Gérald Simonneau, Patrick Petitpretz, Patrice Poubeau, Jacques Cerrina, Pierre Duroux, Ludovic Drouet, Increased plasma serotonin in primary pulmonary hypertension. The American Journal of Medicine. ,vol. 99, pp. 249- 254 ,(1995) , 10.1016/S0002-9343(99)80156-9